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Article

Modeling muscle regeneration in RNA toxicity mice

12 Apr 2021

Abstract excerpt

RNA toxicity underlies the pathogenesis of disorders such as myotonic dystrophy type 1 (DM1). Muscular dystrophy is a key element of the pathology of DM1. The means by which RNA toxicity causes muscular dystrophy in DM1 is unclear. Here, we have used the DM200 mouse model of RNA toxicity due to the expression of a mutant DMPK 3'UTR mRNA to model the effects of RNA toxicity on muscle regeneration. Using a...

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PMID: 33864373
DOI: 10.1093/hmg/ddab108

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