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Article

Pathogenic Variants Associated with Epigenetic Control and the NOTCH Pathway Are Frequent in Classic Hodgkin Lymphoma.

International journal of molecular sciences - 20 Feb 2024

Santisteban-Espejo Antonio, Bernal-Florindo Irene, Montero-Pavon Pedro, Perez-Requena Jose, Atienza-Cuevas Lidia, Fernandez-Valle Maria Del Carmen, Villalba-Fernandez Ana, Garcia-Rojo Marcial

Abstract excerpt

Classic Hodgkin lymphoma (cHL) constitutes a B-cell neoplasm derived from germinal center lymphocytes. Despite high cure rates (80-90%) obtained with the current multiagent protocols, a significant proportion of cHL patients experience recurrences, characterized by a lower sensitivity to second-line treatments. The genomic background of chemorefractory cHL is still poorly understood, limiting personalized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38473705
DOI: 10.3390/ijms25052457
PMCID: PMC10931057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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