Article

Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics

2024-11-18

Abstract excerpt

Sepsis is characterized by life-threatening organ dysfunction caused by dysregulated host response to infection. An underlying cause of sepsis is dysregulation of neutrophil-endothelial interactions. To date, therapeutic approaches are supportive, and there are no effective drugs that target immune dysregulation and alter neutrophil-endothelium function. In our prior investigation, three distinct neutrophil functi...

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Literature Corpus work: 4609bff4-8bad-509a-8805-ee81ed1722e5
DOI: 10.22541/au.173194924.44092721/v1

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