Article
Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.
JCI insight - 1 Nov 2019
Kerchberger V Eric, Bastarache Julie A, Shaver Ciara M, Nagata Hiromasa, McNeil J Brennan, Landstreet Stuart R, Putz Nathan D, Yu Wen-Kuang, Jesse Jordan, Wickersham Nancy E, Sidorova Tatiana N, Janz David R, Parikh Chirag R, Siew Edward D, Ware Lorraine B
Abstract excerpt
Acute respiratory distress syndrome (ARDS) is an inflammatory lung disorder that frequently complicates critical illness and commonly occurs in sepsis. Although numerous clinical and environmental risk factors exist, not all patients with risk factors develop ARDS, raising the possibility of genetic underpinnings for ARDS susceptibility. We have previously reported that circulating cell-free hemoglobin (CFH) is...
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