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Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology

24 Sept 2021

Abstract excerpt

Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These may especially benefit the management of pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high cancer stem cell (CSC) content...

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PMID: 34561461
DOI: 10.1038/s41467-021-25921-9

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