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Targeted sequencing from cerebrospinal fluid for rapid identification of drug-resistant tuberculous meningitis

11 Mar 2024

Abstract excerpt

ABSTRACT Mortality from tuberculous meningitis (TBM) remains around 30%, with most deaths occurring within 2 months of starting treatment. Mortality from drug-resistant strains is higher still, making early detection of drug resistance (DR) essential. Targeted next-generation sequencing (tNGS) produces high read depths, allowing the detection of DR-associated alleles with low frequencies. We applied Deeplex...

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PMID: 38466092
DOI: 10.1128/jcm.01287-23

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