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Causal association of rheumatoid arthritis with frailty and the mediation role of inflammatory cytokines: A Mendelian randomization study.

Archives of gerontology and geriatrics - 1 Jul 2024

Wen Long, Fan Jingwen, Shi Xuezhong, Zhou Huiping, Yang Yongli, Jia Xiaocan

Abstract excerpt

BACKGROUND: Previous observational studies have suggested the association between rheumatoid arthritis (RA) and frailty. However, it remains obscure whether this association is causal. This study aims to investigate the causal association of RA with frailty and the mediation effect of inflammatory cytokines using Mendelian randomization (MR) design. METHODS: Summary-level data for RA (N = 58,284), frailty index...

Topics

Humans
Arthritis, Rheumatoid
Mendelian Randomization Analysis
Frailty
Cytokines
Aged
Genome-Wide Association Study
Male
Female
Mediation Analysis
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 38460264
DOI: 10.1016/j.archger.2024.105348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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