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Article

Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein.

Structure (London, England : 1993) - 7 Apr 2022

Tan Zhen Wah, Tee Wei-Ven, Samsudin Firdaus, Guarnera Enrico, Bond Peter J, Berezovsky Igor N

Abstract excerpt

Recent developments in the SARS-CoV-2 pandemic point to its inevitable transformation into an endemic disease, urging both refinement of diagnostics for emerging variants of concern (VOCs) and design of variant-specific drugs in addition to vaccine adjustments. Exploring the structure and dynamics of the SARS-CoV-2 Spike protein, we argue that the high-mutability characteristic of RNA viruses coupled with the...

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Identifiers

PMID: 35063064
DOI: 10.1016/j.str.2021.12.011
PMCID: PMC8772014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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