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Article

A Pathway Model to Understand the Evolution of Spike Protein Binding to ACE2 in SARS-CoV-2 Variants.

Biomolecules - 31 Oct 2022

Pipitò Ludovico, Reynolds Christopher A, Mobarec Juan Carlos, Vickery Owen, Deganutti Giuseppe

Abstract excerpt

After the SARS-CoV-2 Wuhan variant that gave rise to the pandemic, other variants named Delta, Omicron, and Omicron-2 sequentially became prevalent, with mutations spread around the viral genome, including on the spike (S) protein; in order to understand the resultant in gains in infectivity, we interrogated in silico both the equilibrium binding and the binding pathway of the virus' receptor-binding domain (RBD)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36358957
DOI: 10.3390/biom12111607
PMCID: PMC9687612

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