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Host cell protein networks as a novel co‐elution mechanism during protein A chromatography

7 Mar 2024

Abstract excerpt

Host cell proteins (HCPs) are process-related impurities of therapeutic proteins produced in for example, Chinese hamster ovary (CHO) cells. Protein A affinity chromatography is the initial capture step to purify monoclonal antibodies or Fc-based proteins and is most effective for HCP removal. Previously proposed mechanisms that contribute to co-purification of HCPs with the therapeutic protein are either...

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PMID: 38454640
DOI: 10.1002/bit.28678

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