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Article

Impact of GBA2 on Neuronopathic Gaucher’s Disease and α-Synuclein Accumulation in Medaka (Oryzias Latipes)

2021-02-25

Abstract excerpt

<title>Abstract</title> <p>Homozygous mutations in the lysosomal glucocerebrosidase gene, <italic>GBA1</italic>, cause Gaucher’s disease (GD), while heterozygous mutations in <italic>GBA1</italic> are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal α-synuclein (asyn) aggregates. We previously reported that <italic>GBA1 </italic>knockout (KO) medaka exhibited glucosy...

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Literature Corpus work
4e209366-029e-5ae7-bfd0-e4291432dc5f
DOI
10.21203/rs.3.rs-241251/v1
Open publication

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Impact of GBA2 on Neuronopathic Gaucher’s Disease and α-Synuclein Accumulation in Medaka (Oryzias Latipes)DOI 10.21203/rs.3.rs-241251/v1
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