Article
TSVM: Transfer Support Vector Machine for Predicting MPRA Validated Regulatory Variants.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Li Minglie, Zhou Shusen, Liu Tong, Liu Chanjuan, Zang Mujun, Wang Qingjun
Abstract excerpt
Genome-wide association studies have shown that common genetic variants associated with complex diseases are mostly located in non-coding regions, which may not be causal. In addition, the limited number of validated non-coding functional variants makes it difficult to develop an effective supervised learning model. Therefore, improving the accuracy of predicting non-coding causal variants has become critical....
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