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Article

Histone H2A variant H2A.B is enriched in transcriptionally active and replicating HSV-1 lytic chromatin.

Journal of virology - 16 Apr 2024

Flores Cortes Esteban, Saddoris Sarah M, Owens Arryn K, Gibeault Rebecca, Depledge Daniel P, Schang Luis M

Abstract excerpt

Herpes simplex virus 1 (HSV-1) transcription is restricted in latently infected neurons and the genomes are in mostly silenced chromatin, whereas all viral genes are transcribed in lytically infected cells, in which the genomes are dynamically chromatinized. Epigenetic regulation modulates HSV-1 transcription during lytic, latent, and reactivating infections but the precise mechanisms are not fully defined....

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Share to Chromatin
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38451083
DOI: 10.1128/jvi.02015-23
PMCID: PMC11019955

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