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Article

ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection

28 Apr 2021

Abstract excerpt

Histones are rapidly loaded on the HSV genome upon entry into the nucleus of human fibroblasts, but the effects of histone loading on viral replication have not been fully defined. We showed recently that ATRX is dispensable for de novo deposition of H3 to HSV genomes after nuclear entry but restricted infection through maintenance of viral heterochromatin. To further investigate the roles that ATRX and other...

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PMID: 33909709
DOI: 10.1371/journal.ppat.1009567

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