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Article

NASP gene contributes to autism by epigenetic dysregulation of neural and immune pathways.

Journal of medical genetics - 20 Jun 2024

Zhang Sipeng, Yang Jie, Ji Dandan, Meng Xinyi, Zhu Chonggui, Zheng Gang, Glessner Joseph, Qu Hui-Qi, Cui Yuechen, Liu Yichuan, Wang Wei, Li Xiumei, Zhang Hao, Xiu Zhanjie, Sun Yan, Sun Ling, Li Jie, Hakonarson Hakon, Li Jin, Xia Qianghua

Abstract excerpt

BACKGROUND: Epigenetics makes substantial contribution to the aetiology of autism spectrum disorder (ASD) and may harbour a unique opportunity to prevent the development of ASD. We aimed to identify novel epigenetic genes involved in ASD aetiology. METHODS: Trio-based whole exome sequencing was conducted on ASD families. Genome editing technique was used to knock out the candidate causal gene in a relevant cell...

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Source

Identifiers

PMID: 38443156
DOI: 10.1136/jmg-2023-109385

Genes

NASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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