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Article

Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids.

Proceedings of the National Academy of Sciences of the United States of America - 12 Mar 2024

Bonnet Valentin, Maikranz Erik, Madec Marianne, Vertti-Quintero Nadia, Cuche Céline, Mastrogiovanni Marta, Alcover Andrés, Di Bartolo Vincenzo, Baroud Charles N

Abstract excerpt

Evaluating the ability of cytotoxic T lymphocytes (CTLs) to eliminate tumor cells is crucial, for instance, to predict the efficiency of cell therapy in personalized medicine. However, the destruction of a tumor by CTLs involves CTL migration in the extra-tumoral environment, accumulation on the tumor, antigen recognition, and cooperation in killing the cancer cells. Therefore, identifying the limiting steps in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38442157
DOI: 10.1073/pnas.2316500121
PMCID: PMC10945811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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