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Efficient Isolation and Phenotypic Profiling of Circulating Hepatocellular Carcinoma Cells via a Combinatorial-Antibody-Functionalized Microfluidic Synergetic-Chip.

Analytical chemistry - 17 Nov 2020

Zhu Lin, Lin Huibin, Wan Shuang, Chen Xiaofeng, Wu Lingling, Zhu Zhi, Song Yanling, Hu Bin, Yang Chaoyong

Abstract excerpt

As a malignant disease that seriously threatens human health, hepatocellular carcinoma (HCC) lacks effective early screening and prognostic assessment methods. Herein, we developed a method for efficient capture and multiphenotype analysis of circulating tumor cells (CTCs) of hepatocellular carcinoma. The anti-ASGPR antibody and the anti-EpCAM antibody were modified in parallel on a deterministic lateral...

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Carcinoma, Hepatocellular
Cell Line, Tumor
Cell Separation
Epithelial Cell Adhesion Molecule
Lab-On-A-Chip Devices

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Neoplastic Cells, Circulating

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PMID: 33124804
DOI: 10.1021/acs.analchem.0c03936

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