Article
Prolonged exposure to dexamethasone alters the proteome and cellular phenotype of human testicular peritubular cells.
Proteomics - 1 Aug 2024
Stepanov Youli K, Herrmann Carola, Stöckl Jan B, Köhn Frank-Michael, Pickl Ulrich, Trottmann Mathias, Fröhlich Thomas, Mayerhofer Artur, Welter Harald
Abstract excerpt
Human testicular peritubular cells (HTPCs) are smooth muscle cells, which in the testis form a small compartment surrounding the seminiferous tubules. Contractions of HTPCs are responsible for sperm transport, HTPCs contribute to spermatogenesis, have immunological roles and are a site of glucocorticoid receptor expression. Importantly, HTPCs maintain their characteristics in vitro, and thus can serve as an...
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