Prolonged exposure to dexamethasone alters the proteome and cellular phenotype of human testicular peritubular cells.

doi:10.1002/pmic.202300616

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Article

Prolonged exposure to dexamethasone alters the proteome and cellular phenotype of human testicular peritubular cells.

Proteomics - 1 Aug 2024

Stepanov Youli K, Herrmann Carola, Stöckl Jan B, Köhn Frank-Michael, Pickl Ulrich, Trottmann Mathias, Fröhlich Thomas, Mayerhofer Artur, Welter Harald

Abstract excerpt

Human testicular peritubular cells (HTPCs) are smooth muscle cells, which in the testis form a small compartment surrounding the seminiferous tubules. Contractions of HTPCs are responsible for sperm transport, HTPCs contribute to spermatogenesis, have immunological roles and are a site of glucocorticoid receptor expression. Importantly, HTPCs maintain their characteristics in vitro, and thus can serve as an...

Topics

Humans
Male
Dexamethasone
Proteome
Testis
Proteomics
Phenotype
Myocytes, Smooth Muscle
Seminiferous Tubules
Cells, Cultured
Glucocorticoids

Source

Open in PubMed

Identifiers

PMID: 38419139
DOI: 10.1002/pmic.202300616

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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