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Article

Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.

PLoS computational biology - 29 Aug 2008

Han Sangjo, Kim Dongsup

Abstract excerpt

The chemical-genetic profile can be defined as quantitative values of deletion strains' growth defects under exposure to chemicals. In yeast, the compendium of chemical-genetic profiles of genomewide deletion strains under many different chemicals has been used for identifying direct target proteins and a common mode-of-action of those chemicals. In the previous study, valuable biological information such as...

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Identifiers

PMID: 18769708
DOI: 10.1371/journal.pcbi.1000162
PMCID: PMC2515108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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