Article
CRB1-associated retinal degeneration is dependent on bacterial translocation from the gut.
Cell - 14 Mar 2024
Peng Shanzhen, Li Jing Jing, Song Wanying, Li Ye, Zeng Lei, Liang Qiaoxing, Wen Xiaofeng, Shang Haitao, Liu Keli, Peng Peiyao, Xue Wei, Zou Bin, Yang Liu, Liang Juanran, Zhang Zhihui, Guo Shixin, Chen Tingting, Li Wenxuan, Jin Ming, Xing Xiang-Bin, Wan Pengxia, Liu Chunqiao, Lin Haotian, Wei Hong, Lee Richard W J, Zhang Feng, Wei Lai
Abstract excerpt
The Crumbs homolog 1 (CRB1) gene is associated with retinal degeneration, most commonly Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). Here, we demonstrate that murine retinas bearing the Rd8 mutation of Crb1 are characterized by the presence of intralesional bacteria. While normal CRB1 expression was enriched in the apical junctional complexes of retinal pigment epithelium and colonic...
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