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Article

The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila.

G3 (Bethesda, Md.) - 7 May 2024

Zappia Maria Paula, Damschroder Deena, Westacott Anton, Wessells Robert J, Frolov Maxim V

Abstract excerpt

Robust genetic systems to control the expression of transgenes in a spatial and temporal manner are a valuable asset for researchers. The GeneSwitch system induced by the drug RU486 has gained widespread use in the Drosophila community. However, some concerns were raised as negative effects were seen depending on the stock, transgene, stage, and tissue under study. Here, we characterized the adverse effects...

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Identifiers

PMID: 38409337
DOI: 10.1093/g3journal/jkae039
PMCID: PMC11075533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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