Article
Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase.
Disease models & mechanisms - 29 Dec 2020
Dahl-Halvarsson Martin, Olive Montse, Pokrzywa Malgorzata, Norum Michaela, Ejeskär Katarina, Tajsharghi Homa
Abstract excerpt
Myosin is vital for body movement and heart contractility. Mutations in MYH7, encoding slow/β-cardiac myosin heavy chain, are an important cause of hypertrophic and dilated cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (R1845W) in MYH7 has been reported in several unrelated cases of myosin storage myopathy. We have developed a Drosophila model for a myosin storage myopathy in...
Topics
- Animals
- Animals, Genetically Modified
- Disease Models, Animal
- Drosophila Proteins
- Drosophila melanogaster
- Longevity
- Movement
- Muscle, Skeletal
- Muscular Diseases
- Mutation
- Myosin Heavy Chains
- Time Factors
- Tripartite Motif Proteins