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Article

Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase.

Disease models & mechanisms - 29 Dec 2020

Dahl-Halvarsson Martin, Olive Montse, Pokrzywa Malgorzata, Norum Michaela, Ejeskär Katarina, Tajsharghi Homa

Abstract excerpt

Myosin is vital for body movement and heart contractility. Mutations in MYH7, encoding slow/β-cardiac myosin heavy chain, are an important cause of hypertrophic and dilated cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (R1845W) in MYH7 has been reported in several unrelated cases of myosin storage myopathy. We have developed a Drosophila model for a myosin storage myopathy in...

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Identifiers

PMID: 33234710
DOI: 10.1242/dmm.047886
PMCID: PMC7790189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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