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Article

Spatial and temporal control of gene expression in Drosophila using the inducible GeneSwitch GAL4 system. I. Screen for larval nervous system drivers.

Genetics - 1 Jan 2008

Nicholson Louise, Singh Gunisha K, Osterwalder Thomas, Roman Gregg W, Davis Ronald L, Keshishian Haig

Abstract excerpt

There is a critical need for genetic methods for the inducible expression of transgenes in specific cells during development. A promising approach for this is the GeneSwitch GAL4 system of Drosophila. With GeneSwitch GAL4 the expression of upstream activating sequence (UAS) effector lines is controlled by a chimeric GAL4 protein that becomes active in the presence of the steroid RU486 (mifepristone). To improve...

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PMID: 18202369
DOI: 10.1534/genetics.107.081968
PMCID: PMC2206072

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