Article
A custom next-generation sequencing panel for 1p/19q codeletion and mutational analysis in gliomas.
Journal of neuropathology and experimental neurology - 20 Mar 2024
Qi Peng, Yao Qian-Lan, Lao I Weng, Ren Min, Bai Qian-Ming, Cai Xu, Xue Tian, Wei Ran, Zhou Xiao-Yan
Abstract excerpt
The World Health Organization has updated their classification system for the diagnosis of gliomas, combining histological features with molecular data including isocitrate dehydrogenase 1 and codeletion of chromosomal arms 1p and 19q. 1p/19q codeletion analysis is commonly performed by fluorescence in situ hybridization (FISH). In this study, we developed a 57-gene targeted next-generation sequencing (NGS) panel...
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