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Article

The mediating role of atrial fibrillation in causal associations between risk factors and stroke: a Mendelian randomization study.

Epidemiology and health - 1 Jan 2024

Qin Shanmei, Wang Mengmeng, Gill Dipender, Zhang Zhizhong, Liu Xinfeng

Abstract excerpt

OBJECTIVES: Atrial fibrillation (AF) contributes to stroke development and progression. We aimed to quantify the mediating role of AF in the causal associations between a wide range of risk factors and stroke via a Mendelian randomization (MR) framework. METHODS: We assessed the associations of 108 traits with stroke and its subtypes in a 2-sample univariable MR approach, then conducted a bidirectional MR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38404113
DOI: 10.4178/epih.e2024005
PMCID: PMC11040217

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