Article
SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions.
International journal of molecular sciences - 16 Feb 2024
Timilsina Uddhav, Ivey Emily B, Duffy Sean, Plianchaisuk Arnon, The Genotype To Phenotype Japan G P-Japan Consortium, Ito Jumpei, Sato Kei, Stavrou Spyridon
Abstract excerpt
A feature of the SARS-CoV-2 Omicron subvariants BF.5 and BF.7 that recently circulated mainly in China and Japan was the high prevalence of the ORF7a: H47Y mutation, in which the 47th residue of ORF7a has been mutated from a histidine (H) to a tyrosine (Y). Here, we evaluated the effect of this mutation on the three main functions ascribed to the SARS-CoV-2 ORF7a protein. Our findings show that H47Y mutation...
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