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Neuroaxonal Dystrophy Caused by Group VIA Phospholipase A<sub>2</sub>Deficiency in Mice: A Model of Human Neurodegenerative Disease

27 Feb 2008

Abstract excerpt

Calcium-independent group VIA phospholipase A2 (iPLA2beta) is considered to play a role in signal transduction and maintenance of homeostasis or remodeling of membrane phospholipids. A role of iPLA2beta has been suggested in various physiological and pathological processes, including immunity, chemotaxis, and cell death, but the details remain unclear. Accordingly, we investigated mice with targeted disruption of...

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PMID: 18305254
DOI: 10.1523/jneurosci.4354-07.2008

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