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Article

Evidence for sex differences in the impact of cytochrome P450 genotypes on early subjective effects of cannabis.

Addictive behaviors - 1 Jun 2024

Davis Christal N, Markowitz John S, Squeglia Lindsay M, Ellingson Jarrod M, McRae-Clark Aimee L, Gray Kevin M, Kretschmer Diana, Tomko Rachel L

Abstract excerpt

Early positive subjective effects of cannabis predict the development of cannabis use disorder (CUD). Genetic factors, such as the presence of cytochrome P450 genetic variants that are associated with reduced Δ9-tetrahydrocannabinol (THC) metabolism, may contribute to individual differences in subjective effects of cannabis. Young adults (N = 54) with CUD or a non-CUD substance use disorder (control) provided a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38394959
DOI: 10.1016/j.addbeh.2024.107996
PMCID: PMC10947802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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