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HIV-1 integrase resistance associated mutations and the use of dolutegravir in Sub-Saharan Africa: a systematic review and meta-analysis protocol.

Systematic reviews - 25 Apr 2020

Semengue Ezechiel Ngoufack Jagni, Santoro Maria Mercedes, Ndze Valantine Ngum, Dambaya Beatrice, Takou Desiré, Teto Georges, Nka Alex Durand, Fabeni Lavinia, Wiyeh Alison, Ceccherini-Silberstein Francesca, Colizzi Vittorio, Perno Carlo-Federico, Fokam Joseph

Abstract excerpt

BACKGROUND: Sub-Saharan Africa carries the greatest burden of HIV-infection with increasing drug resistance burden, which requires improved patient management and monitoring. Current WHO recommendations suggest transitioning to dolutegravir-based (adults) or raltegravir-based-regimens (neonates) for initial antiretroviral therapy (ART) and as a suitable alternative in cases of multi-resistance in resource-limited...

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PMID: 32334643
DOI: 10.1186/s13643-020-01356-z
PMCID: PMC7183126

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