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Article

Sertoli cell‐derived exosome‐mediated transfer of miR‐145‐5p inhibits Leydig cell steroidogenesis by targeting steroidogenic factor 1

19 May 2021

Abstract excerpt

In the mammalian testis, two distinct populations of Sertoli cells (SCs), the immature SCs (ISCs) and adult SCs (ASCs), play significant roles in regulating the development and function of Leydig cells. However, the effect of different SC types on the function of Leydig cells is poorly understood. Here, our study showed that miR-145-5p expression was significantly different in SCs at different stages, with the...

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PMID: 34010469
DOI: 10.1096/fj.202002589rrrr

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