Article
Mitochondrial diseases: from molecular mechanisms to therapeutic advances.
Signal transduction and targeted therapy - 10 Jan 2025
Wen Haipeng, Deng Hui, Li Bingyan, Chen Junyu, Zhu Junye, Zhang Xian, Yoshida Shigeo, Zhou Yedi
Abstract excerpt
Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochondrial genetic disorders can arise from a wide range of mutations in either mitochondrial or nuclear DNA, which encode mitochondrial proteins or other contents. These genetic...
Read the complete abstract on PubMedTopics
- Humans
- Mitochondrial Diseases
- Mitochondria
- Oxidative Phosphorylation
- DNA, Mitochondrial
- Mutation