Article
Mitochondrial disorders affecting the nervous system.
Seminars in neurology - 1 Jul 2014
Haas R H, Zolkipli Z
Abstract excerpt
Mitochondrial diseases are multiorgan system disorders and the brain is the most commonly affected organ. The high-energy requirement of the brain leaves it vulnerable to energy failure. All components of the neuraxis including muscle, the neuromuscular junction, peripheral nerve, spinal cord, and brain can be affected. Genetic mitochondrial disease can be caused by nuclear gene defects and mitochondrial DNA...
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