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Article

Design and high-throughput implementation of MALDI-TOF/MS-based assays for Parkin E3 ligase activity.

Cell reports methods - 26 Feb 2024

Traynor Ryan, Moran Jennifer, Stevens Michael, Antico Odetta, Knebel Axel, Behrouz Bahareh, Merchant Kalpana, Hastie C James, Davies Paul, Muqit Miratul M K, De Cesare Virginia

Abstract excerpt

Parkinson's disease (PD) is a progressive neurological disorder that manifests clinically as alterations in movement as well as multiple non-motor symptoms including but not limited to cognitive and autonomic abnormalities. Loss-of-function mutations in the gene encoding the ubiquitin E3 ligase Parkin are causal for familial and juvenile PD. Among several therapeutic approaches being explored to treat or improve...

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Identifiers

PMID: 38382522
DOI: 10.1016/j.crmeth.2024.100712
PMCID: PMC10921019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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