Article
Genetic influences on circulating retinol and its relationship to human health.
Nature communications - 19 Feb 2024
Reay William R, Kiltschewskij Dylan J, Di Biase Maria A, Gerring Zachary F, Kundu Kousik, Surendran Praveen, Greco Laura A, Clarke Erin D, Collins Clare E, Mondul Alison M, Albanes Demetrius, Cairns Murray J
Abstract excerpt
Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughout the human lifespan. Here, we perform the largest genome-wide association study (GWAS) of retinol to date in up to 22,274 participants. We identify eight common variant loci associated with retinol, as well as a rare-variant signal. An integrative gene prioritisation pipeline supports novel retinol-associated...
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