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Article

An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaV1.1 underlying Dravet syndrome.

Stem cell reports - 8 Aug 2023

Doorn Nina, van Hugte Eline J H, Ciptasari Ummi, Mordelt Annika, Meijer Hil G E, Schubert Dirk, Frega Monica, Nadif Kasri Nael, van Putten Michel J A M

Abstract excerpt

Human induced pluripotent stem cell (hiPSC)-derived neuronal networks on multi-electrode arrays (MEAs) provide a unique phenotyping tool to study neurological disorders. However, it is difficult to infer cellular mechanisms underlying these phenotypes. Computational modeling can utilize the rich dataset generated by MEAs, and advance understanding of disease mechanisms. However, existing models lack biophysical...

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Identifiers

PMID: 37419110
DOI: 10.1016/j.stemcr.2023.06.003
PMCID: PMC10444571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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