Article
A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma.
Nature communications - 31 Aug 2021
Zhou Xiang, Cao Su-Mei, Cai Yong-Lin, Zhang Xiao, Zhang Shanshan, Feng Guo-Fei, Chen Yufeng, Feng Qi-Sheng, Chen Yijun, Chang Ellen T, Liu Zhonghua, Adami Hans-Olov, Liu Jianjun, Ye Weimin, Zhang Zhe, Zeng Yi-Xin, Xu Miao
Abstract excerpt
Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs,...
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