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Article

Inflamed immune phenotype predicts favorable clinical outcomes of immune checkpoint inhibitor therapy across multiple cancer types.

Journal for immunotherapy of cancer - 14 Feb 2024

Shen Jeanne, Choi Yoon-La, Lee Taebum, Kim Hyojin, Chae Young Kwang, Dulken Ben W, Bogdan Stephanie, Huang Maggie, Fisher George A, Park Sehhoon, Lee Se-Hoon, Hwang Jun-Eul, Chung Jin-Haeng, Kim Leeseul, Song Heon, Pereira Sergio, Shin Seunghwan, Lim Yoojoo, Ahn Chang Ho, Kim Seulki, Oum Chiyoon, Kim Sukjun, Park Gahee, Song Sanghoon, Jung Wonkyung, Kim Seokhwi, Bang Yung-Jue, Mok Tony S K, Ali Siraj M, Ock Chan-Young

Abstract excerpt

BACKGROUND: The inflamed immune phenotype (IIP), defined by enrichment of tumor-infiltrating lymphocytes (TILs) within intratumoral areas, is a promising tumor-agnostic biomarker of response to immune checkpoint inhibitor (ICI) therapy. However, it is challenging to define the IIP in an objective and reproducible manner during manual histopathologic examination. Here, we investigate artificial intelligence...

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Identifiers

PMID: 38355279
DOI: 10.1136/jitc-2023-008339
PMCID: PMC10868175

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