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Article

The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function.

American journal of human genetics - 7 Mar 2024

Zhang Jianhua, Pandey Mritunjay, Awe Adam, Lue Nicole, Kittock Claire, Fikse Emma, Degner Katherine, Staples Jenna, Mokhasi Neha, Chen Weiping, Yang Yanqin, Adikaram Poorni, Jacob Nirmal, Greenfest-Allen Emily, Thomas Rachel, Bomeny Laura, Zhang Yajun, Petros Timothy J, Wang Xiaowen, Li Yulong, Simonds William F

Abstract excerpt

Disease-associated variants identified from genome-wide association studies (GWASs) frequently map to non-coding areas of the genome such as introns and intergenic regions. An exclusive reliance on gene-agnostic methods of genomic investigation could limit the identification of relevant genes associated with polygenic diseases such as Alzheimer disease (AD). To overcome such potential restriction, we developed a...

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Identifiers

PMID: 38354736
DOI: 10.1016/j.ajhg.2024.01.005
PMCID: PMC10940018

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