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Article

Intervention of Tanshinone IIA on the PGK1-PDHK1 Pathway to Reprogram Macrophage Phenotype After Myocardial Infarction.

Cardiovascular drugs and therapy - 1 Dec 2024

Gao Shan, Yang Zhihui, Li Dan, Wang Bingkai, Zheng Xu, Li Chong, Fan Guanwei

Abstract excerpt

BACKGROUND: Myocardial infarction remains a disease with high morbidity and death rate among cardiovascular diseases. Macrophages are abundant immune cells in the heart. Under different stimulatory factors, macrophages can differentiate into different phenotypes and play a dual pro-inflammatory and anti-inflammatory role. Therefore, a potential strategy for the treatment of myocardial infarction is to regulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37991600
DOI: 10.1007/s10557-023-07520-6

Genes

PGK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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