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Article

Complement C3c Reflects Acute-Phase Response but Not Clinical Phenotype in Systemic Sclerosis: A Cross-Sectional Study.

International journal of molecular sciences - 28 Jun 2026

Trefler Jakub, Pasierb Anna, Lech Lidia, Czaplicki Hubert, Życińska Katarzyna

Abstract excerpt

This study evaluated routinely measured serum complement C3c (C3c) and complement C4 (C4) in relation to systemic inflammation, clinical and immunological phenotypes, and patient-reported outcomes (PROs) in systemic sclerosis (SSc). Seventy SSc patients fulfilling the 2013 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria underwent same-day assessment including serum C3c,...

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Identifiers

PMID: 42450111
DOI: 10.3390/ijms27135839
PMCID: PMC13361302

Genes

CRP
ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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