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Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

1 Feb 2024

Abstract excerpt

Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings revealed that ectopic expression of the pluripotency transcription factor NANOG rejuvenates dysfunctional mitochondria of senescent cells by rewiring metabolic pathways. In this...

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PMID: 38354087
DOI: 10.1016/j.celrep.2024.113738

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