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Article

Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2024

Benzow Kellie, Karanjeet Kul, Oblak Adrian L, Carter Gregory W, Sasner Michael, Koob Michael D

Abstract excerpt

INTRODUCTION: Genetic studies conducted over the past four decades have provided us with a detailed catalog of genes that play critical roles in the etiology of Alzheimer's disease (AD) and related dementias (ADRDs). Despite this progress, as a field we have had only limited success in incorporating this rich complexity of human AD/ADRD genetics findings into our animal models of these diseases. Our primary goal...

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Identifiers

PMID: 38343132
DOI: 10.1002/alz.13730
PMCID: PMC11032548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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