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N-Acetylcysteine Alters Disease Progression and Increases Janus Kinase Mutation Frequency in a Mouse Model of Precursor B-Cell Acute Lymphoblastic Leukemia.

The Journal of pharmacology and experimental therapeutics - 15 Mar 2024

Sams Mia P, Iansavitchous James, Astridge Madeline, Rysan Heidi, Xu Li S, Rodrigues de Oliveira Bruno, DeKoter Rodney P

Abstract excerpt

B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent type of cancer in young children and is associated with high levels of reactive oxygen species (ROS). The antioxidant N-acetylcysteine (NAC) was tested for its ability to alter disease progression in a mouse model of B-ALL. Mb1-CreΔPB mice have deletions in genes encoding PU.1 and Spi-B in B cells and develop B-ALL at 100% incidence. Treatment of...

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PMID: 38336380
DOI: 10.1124/jpet.123.002000

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N-Acetylcysteine Alters Disease Progression and Increases Janus Kinase Mutation Frequency in a Mouse Model of Precursor B-Cell Acute Lymphoblastic Leukemia.PMID 38336380Read ↗

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