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SIRT2 regulates apoptosis by inducing mitophagy in sheep cumulus cells

3 Feb 2024

Abstract excerpt

Cumulus cells surrounding oocytes furnish nutritional support crucial for oocyte maturation in vitro , and thereby enhance oocyte quality significantly. Our previous studies affirmed the role of SIRT2 in regulation of mitochondrial function in sheep granulosa cells . However, the effect of SIRT2 action on mitophagy in these cells remain unclear. Here, RNA-seq was used to scrutinize pathways where differentially...

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PMID: 38330860
DOI: 10.1016/j.theriogenology.2024.02.004

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