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Article

Role of <i>Sirt3</i> in mitochondrial biogenesis and developmental competence of human <i>in vitro</i> matured oocytes

18 Jan 2016

Abstract excerpt

STUDY QUESTION: Does Sirt3 dysfunction result in poor developmental outcomes for human oocytes after in vitro maturation (IVM)? SUMMARY ANSWER: Inefficient Sirt3 expression induced decreased mitochondrial DNA copy number and biogenesis, and therefore impaired the developmental competence of human IVM oocytes. WHAT IS KNOWN ALREADY: Cytoplasmic immaturity in IVM oocytes may lead to reduced developmental...

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PMID: 26787646
DOI: 10.1093/humrep/dev345

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