Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.

Clinical medicine (London, England) - 1 Jun 2015

Kasapoglu Benan, Turkay Cansel, Yalcin Kadir Serkan, Kosar Ali, Bozkurt Alper

Abstract excerpt

Common genetic mutations encountered in folate metabolism may result in increased homocysteine (Hcy) levels. It has been reported that increased serum Hcy levels may affect the intracellular fat metabolism and may cause enhanced fatty infiltration in the liver resulting in non-alcoholic fatty liver disease (NAFLD). In total, 150 patients diagnosed with FLD by ultrasound examination and 136 healthy control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Folic Acid
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mutation

Share to Non-alcoholic Fatty Liver Disease

Share to Vitamin B 12

Source

Open in PubMed Open full text

Identifiers

PMID: 26031974
DOI: 10.7861/clinmedicine.15-3-248
PMCID: PMC4953108

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.PMID 26031974Read ↗

Plasmatic higher levels of homocysteine in non-alcoholic fatty liver disease (NAFLD).Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene polymorphism and serum homocysteine levels in nonalcoholic fatty liver disease.Semantic proximity Read ↗

Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism.Semantic proximity Read ↗

Associations between Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms and Non-Alcoholic Fatty Liver Disease (NAFLD) Risk: A Meta-Analysis.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T mutation and nonalcoholic fatty liver disease.Semantic proximity Read ↗

Association between homocysteine and nonalcoholic fatty liver disease: Mendelian randomisation studySemantic proximity Read ↗

Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.Semantic proximity Read ↗

One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics.Semantic proximity Read ↗

Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk.Semantic proximity Read ↗

Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients†‡Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil.Semantic proximity Read ↗

Nonalcoholic fatty liver disease and HFE gene mutations: a Polish study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.