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Article

Influence of genetic polymorphisms in vascular endothelial-related genes on the clinical outcome of axitinib in patients with metastatic renal cell carcinoma.

Cancer biology & therapy - 31 Dec 2024

Numakura Kazuyuki, Igarashi Ryoma, Takahashi Makoto, Nara Taketoshi, Kanda Sohei, Saito Mitsuru, Narita Shintaro, Inoue Takamitsu, Niioka Takenori, Miura Masatomo, Habuchi Tomonori

Abstract excerpt

OBJECTIVE: Axitinib is an oral multi-target tyrosine kinase inhibitor used for the treatment of renal cell carcinoma (RCC). Because of the severe adverse events (AEs) associated with axitinib, patients often need dose reductions or discontinue its use, highlighting the need for effective biomarkers to assess efficacy and/or AEs. The aim of this study was to investigate the relationship between single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38327067
DOI: 10.1080/15384047.2024.2312602
PMCID: PMC10857686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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