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Article

Association of axitinib plasma exposure and genetic polymorphisms of ABC transporters with axitinib-induced toxicities in patients with renal cell carcinoma.

Cancer chemotherapy and pharmacology - 1 Oct 2016

Kato Hiroshi, Sassa Naoto, Miyazaki Masayuki, Takeuchi Mio, Asai Miho, Iwai Akane, Noda Yukihiro, Gotoh Momokazu, Yamada Kiyofumi

Abstract excerpt

PURPOSE: Axitinib is a selective tyrosine kinase inhibitor of VEGF receptors, approved for advanced renal cell carcinoma (RCC). Associations between axitinib plasma exposure, genetic polymorphisms of ABC transporters and axitinib-induced toxicities have not been adequately explored. METHODS: Twenty RCC patients treated with axitinib were enrolled in this study. Blood samples were collected 0, 0.5, 1, 2, 4, and...

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Source

Identifiers

PMID: 27586968
DOI: 10.1007/s00280-016-3145-0

Genes

ABCB1
ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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