Article
N123I mutation in the ALV-J receptor-binding domain region enhances viral replication ability by increasing the binding affinity with chNHE1.
PLoS pathogens - 1 Feb 2024
Yu Mengmeng, Zhang Yao, Zhang Li, Wang Suyan, Liu Yongzhen, Xu Zhuangzhuang, Liu Peng, Chen Yuntong, Guo Ru, Meng Lingzhai, Zhang Tao, Fan Wenrui, Qi Xiaole, Gao Li, Zhang Yanping, Cui Hongyu, Gao Yulong
Abstract excerpt
The subgroup J avian leukosis virus (ALV-J), a retrovirus, uses its gp85 protein to bind to the receptor, the chicken sodium hydrogen exchanger isoform 1 (chNHE1), facilitating viral invasion. ALV-J is the main epidemic subgroup and shows noteworthy mutations within the receptor-binding domain (RBD) region of gp85, especially in ALV-J layer strains in China. However, the implications of these mutations on viral...
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