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Gene copy number, gene configuration and LC / HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines

6 Feb 2024

Abstract excerpt

The augmentation of transgene copy numbers is a prevalent approach presumed to enhance transcriptional activity and product yield. CHO cell lines engineered via targeted integration (TI) offer an advantageous platform for investigating the interplay between gene copy number, mRNA abundance, product yield, and product quality. Our investigation revealed that incrementally elevating the gene copy numbers of both...

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PMID: 38321634
DOI: 10.1002/btpr.3433

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